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Nobel Prize in Physiology or Medicine 2025 Awarded to Shimon Sakaguchi, Mary E. Brunkow, and Fred Ramsdell.

Awards | Dated: 08 Oct 2025

On October 6, 2025, the Nobel Assembly at Karolinska Institutet in Stockholm, Sweden, recently declared Shimon Sakaguchi, Mary E. Brunkow, and Fred Ramsdell as the winners of the Nobel Prize in Physiology or Medicine 2025 for their groundbreaking discoveries on peripheral immune tolerance, which prevents the immune system from attacking the body.

🎯 Key Highlights:

  • - The awards will be presented on December 10, marking the anniversary of Alfred Nobel’s death.

💡 Other Important Facts:

  • (i) In 1995, Shimon Sakaguchi identified a subset of T cells that suppress immune responses, preventing autoimmune diseases. These cells, termed regulatory T cells (Tregs), revealed that the immune system has a built-in mechanism to avoid harming the body’s own tissues.
  • (ii) In 2001, Mary E. Brunkow discovered that mutations in the FOXP3 gene caused a fatal autoimmune disease in mice. Her research showed that FOXP3 (scurfin) is essential for the development and proper function of Tregs.
  • (iii) The combined work of Sakaguchi, Brunkow, and Ramsdell has significantly advanced the understanding of immune regulation, providing insights into autoimmune diseases and paving the way for therapeutic interventions that can enhance or suppress immune responses.

📚 Test Your Knowledge:

Which Japanese immunologist was recently awarded the Nobel Prize in Physiology or Medicine 2025 for discovering regulatory T cells (Tregs)?

Correct Answer: Shimon Sakaguchi

🚀 Quick Recap:

About Nobel Assembly

  • Chair : Astrid Soderbergh Widding
  • Headquarters : Stockholm, Sweden